Dr. Douglas Gladue
Douglas Gladue, PhD is a Senior Scientist at the USDA Plum Island Animal Disease Center focusing on rationally designed vaccines for foreign swine diseases including African swine fever virus (ASFV). Dr. Gladue started his research on swine diseases in 2007 focusing his research on developing a novel rationally designed ASFV vaccine. Currently he is co-inventor on four effective live attenuated vaccine platforms against ASFV. His recent accomplishments include adaptation of ASFV vaccines to stable cell lines, allowing for commercialization. Identification of a stable cell line for ASFV diagnostics. The functional characterization of ASFV proteins and the development of new methodology for independent multiple deletions in the ASFV genome, allowing for safer ASFV vaccine design strategies. Dr. Gladue was elected as the Scientific Director for the global alliance for ASFV (GARA). He is currently working with selected commercial partners to bring his experimental ASFV vaccines to commercialization.
Other than ASFV, his research interests also include classical swine fever virus (CSFV) and foot-and-mouth disease virus (FMDV), where he has focused on the molecular mechanisms of viral pathogenesis and virus-host protein interactions and applying these discoveries to the design of rational vaccines. He has discovered over one hundred host-viral protein interactions and has used this discovery combined with a custom computational pipeline involving both bioinformatics and functional genomic data, to identify critical domains in viral proteins. Dr. Gladue has served on multiple scientific committees, grant review panels, and authored numerous peer-reviewed scientific publications. He currently serves as an editor for several scientific journals, and as treasure-elect for the world society of virology.