Speakers(Updating) » Qiuhong Wang

Qiuhong Wang

Dr. Qiuhong Wang is an Associate Professor and virologist at Department of Veterinary Preventive Medicine, The Ohio State University. Dr. Wang has established a focused and highly productive research program on porcine coronaviruses and animal and human caliciviruses: 1) Elucidate mechanisms for molecular attenuation of porcine epidemic diarrhea virus (PEDV). Dr. Wang’s lab successfully adapted several US PEDV strains to cell culture. Subsequently, they studied cross-reactivity between PEDV variants and between PEDV and TGEV, developed specific diagnostic assays, and studied cross-protection between PEDV variants in pigs to assess vaccine candidates. Most significantly Dr. Wang was the first to establish a stable infectious clone of a highly virulent PEDV strain to identify the genetic factors related to virulence of PEDV for the rational design of attenuated vaccines. 2) Develop safe and effective PEDV vaccines. Safe and effective PEDV vaccines are urgently needed but are not available. Because PEDV is an enteric virus, live attenuated vaccines (LAV) are critical in providing better protection than subunit or inactivated vaccines. However, conventional LAVs, generated by passaging the virus in cell culture to obtain attenuated strains, are unsafe because they either revert to virulent strains or recombine with wild-type virus to generate new virulent viruses. To solve these problems, her aim is to use reverse genetics technology to rationally design effective PEDV LAVs that are safe and unable to revert or recombine with field strains. 3) Study the role of norovirus in food safety. Noroviruses (NoVs) are the leading cause of gastroenteritis outbreaks in humans worldwide, including in children in developed countries. Salad crops and fruits are major vehicles for human NoV transmission. Histo-blood group antigens (HBGAs) are carbohydrates that are attachment factors for NoV infection of humans. Dr. Wang found the presence of HBGA-like carbohydrates in lettuce, to which human NoVs specifically bind. Importantly, her lab found that human NoVs can enter the roots and edible leaves of lettuce via contaminated irrigation water. Thus, human NoVs specifically bound to lettuce, cannot be removed by simple washing, allowing viral transmission to consumers.  Since 2013 when she became an Assistant Professor, she has published 57 (84 total, two papers spotlighted in Appl Environ Microbiol) peer reviewed papers, 3 book chapters, and 38 abstracts. She has successfully secured 7 grants as PI (from NIH, USDA, NPB, etc.) totaling $1,898,475. She has been awarded Outstanding Reviewer by Veterinary Microbiology in 2015-2016. She has been invited to serve on peer review panels for NIH and USDA. She has presented 10 talks at international conferences and 20 invited talks. Currently, she is the Chair of NC1202 Enteric Diseases of Food Animals: Enhanced Prevention, Control and Food Safety, NIFA, USDA. She has advised 4 PhD and 2 Master students, 4 post-docs, 10 Visiting Scholars, 2 Research Assistants, and 7 summer undergraduate/high school students. Her mentees have received awards including the OSU Distinguished Diversity Enhancement Award, conference presentation awards, and travel awards.

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